February 4, 2022
Prof. Dr. med. Philipp Steven
Curriculum Vitae
Department of Ophthalmology
Ocular Surface Group
Competence Center for Ocular GvHD
University of Cologne
50937 Cologne, GERMANY
Tel. (+49)-221-478 97790
Fax. (+49)-221-478 97536
Email: philipp.steven@uk-koeln.de
Scientific career
1996-2003 Study of Medicine at the Christian-Albrechts-University of Kiel
2000, 2003 Research sabbaticals at the Institute of Anatomy and Centenary Institute, University of Sydney, Australia
2003 M.D. (magna cum laude) at the Christian-Albrechts-University of Kiel
2004-2006 Resident of Ophthalmology and Head of the Laboratory for Experimental Ophthalmology, Eye Hospital, University of Lübeck
2006-2008 Postdoctoral fellow at Institute of Anatomy, University of Lübeck (Laboratory of Prof. Dr. Andreas Gebert)
2007- Principal Investigator, Ocular Surface Group
2009 Board Certificate (Facharzt) for Ophthalmology
2011 Habilitation and Venia Legendi at the Faculty of Medicine, University of Lübeck
2011- Clinician-Scientist at the Department of Ophthalmology, University of Cologne
2013-2015 Board Member, Section Young Ophthalmologists, German Ophthalmological Society
2014- Principal Investigator, Cluster of Excellence CECAD, University of Cologne
2014 Habilitation and Venia Legendi at the Faculty of Medicine, University of Cologne
2014- Speaker and Director Competence Center for Ocular GvHD
2015- Principal Investigator of Central Project 1 “Cologne Experimental Eye Imaging Center (CEE-IC)” of the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne
2016- Scientist in the Horizons 2020 research consortium ARREST BLINDNESS, funded by the European Union, an associated project of the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne
2018- Principal Investigator of Project N1 “Lymph- and hemangiogenesis in ocular Graft-versus-Host Disease” of the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne
2018- Co-Applicant of of Central Project C1 “Cologne Experimental Eye Imaging Center (CEE-IC)” of the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne
Prizes and honors
2002 Dry Eye Research Prize, German Ophthalmological Society, Berlin
2007 Dry Eye Research Prize, German Ophthalmological Society, Berlin
2008 Dry Eye Research Prize, German Ophthalmological Society, Berlin
2008 Heinrich Dräger Research Prize
2009 Dry Eye Research Prize, German Ophthalmological Society, Berlin
2016 Clinical Applications part of the two-part Science Prize for Dry Eye and Blepharitis/Meibom-Gland-Dysfunction (MGD), German Ophthalmological Society, Berlin
Selected publications
Wolff D, Radojcic V, Lafyatis R, Cinar R, Rosenstein RK, Cowen EW, Cheng GS, Sheshadri A, Bergeron A, Williams KM, Todd JL, Teshima T, Cuvelier GDE, Holler E, McCurdy SR, Jenq RR, Hanash AM, Jacobsohn D, Santomasso BD, Jain S, Ogawa Y, Steven P, Luo ZK, Dietrich-Ntoukas T, Saban D, Bilic E, Penack O, Griffith LM, Cowden M, Martin PJ, Greinix HT, Sarantopoulos S, Socie G, Blazar BR, Pidala J, Kitko CL, Couriel DR, Cutler C, Schultz KR, Pavletic SZ, Lee SJ, Paczesny S. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report. Transplant Cell Ther. 2021 Oct;27(10):817-835.
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report. Transplant Cell Ther. 2021 Jul;27(7):545-557.
Gehlsen U, Stary D, Maass M, Riesner K, Musial G, Stern ME, Penack O, Steven P. Ocular Graft-versus-Host Disease in a Chemotherapy-Based Minor-Mismatch Mouse Model Features Corneal (Lymph-) Angiogenesis. Int J Mol Sci. 2021 Jun 8;22(12):6191.
Setu MAK, Horstmann J, Schmidt S, Stern ME, Steven P. Deep learning-based automatic meibomian gland segmentation and morphology assessment in infrared meibography. Sci Rep. 2021 Apr 7;11(1):7649.
Tahmaz V, Wiesen MHJ, Gehlsen U, Sauerbier L, Stern ME, Holtick U, Gathof B, Scheid C, Müller C, Steven P. Detection of systemic immunosuppressants in autologous serum eye drops (ASED) in patients with severe chronic ocular graft versus host disease. Graefes Arch Clin Exp Ophthalmol. 2021 Jan;259(1):121-128. doi: 10.1007/s00417-02004865-8. Epub 2020 Aug 19. PMID: 32812133; PMCID: PMC7790777.
Gehlsen U, Siebelmann S, Steven P. Tolerance and Adherence to Cationic 0.1% Cyclosporine in Ocular Graft-versus-Host Disease. Ophthalmic Res. 2021;64(1):77-84. doi: 10.1159/000509034. Epub 2020 May 29. PMID: 32474565.
Steven P, Schwab S, Kiesewetter A, Saban DR, Stern ME, Gehlsen U. Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy. Int J Mol Sci. 2020 Oct 12;21(20):7514.
Steven P, Faust C, Holtick U, Scheid C, Tahmaz V, Stern ME, Gehlsen U. Adverse environmental conditions are a risk factor for ocular GvHD after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant. 2020 Sep;55(9):1851-1853. doi: 10.1038/s41409-020-0824-6. Epub 2020 Feb 10. PMID:
32042103.
Eberwein P, Krösser S, Steven P. Semifluorinated Alkane Eye Drops in Chronic Ocular Graft-versus-Host Disease: A Prospective, Multicenter, Noninterventional Study. Ophthalmic Res. 2020;63(1):50-58. doi: 10.1159/000499158. Epub 2019 May 22. PMID: 31117087.
Cursiefen C, Bock F, Clahsen T, Regenfuss B, Reis A, Steven P, Heindl LM, Bosch JJ, Hos D, Eming S, Grajewski R, Heiligenhaus A, Fauser S, Austin J, Langmann T. [New Therapeutic Approaches in Inflammatory Diseases of the Eye – Targeting Lymphangiogenesis and Cellular Immunity: Research Unit FOR 2240 Presents Itself]. Klin Monbl Augenheilkd. 2017 May;234(5):679-685.
Steven P, Braun T, Krösser S, Gehlsen U. [Influence of Aging on Severity and Anti-Inflammatory Treatment of Experimental Dry Eye Disease]. Klin Monbl Augenheilkd. 2017 May;234(5):662-669.
Gehlsen U, Braun T, Notara M, Krösser S, Steven P. A semifluorinated alkane (F4H5) as novel carrier for cyclosporine A: a promising therapeutic and prophylactic option for topical treatment of dry eye. Graefes Arch Clin Exp Ophthalmol. 2017 Apr;255(4):767-775.
Siebelmann S, Gehlsen U, Le Blanc C, Stanzel TP, Cursiefen C, Steven P. Detection of graft detachments immediately following Descemet membrane endothelial keratoplasty (DMEK) comparing time domain and spectral domain OCT. Graefes Arch Clin Exp Ophthalmol. 2016 Dec;254(12):2431-2437.
Siebelmann S, Bachmann B, Lappas A, Dietlein T, Hermann M, Roters S, Cursiefen C, Steven P. [Intraoperative optical coherence tomography in corneal and glaucoma surgical procedures]. Ophthalmologe. 2016 Aug;113(8):646-50.
Siebelmann S, Bachmann B, Lappas A, Dietlein T, Steven P, Cursiefen C. [Intraoperative optical coherence tomography for examination of newborns and infants under general anesthesia]. Ophthalmologe. 2016 Aug;113(8):651-5.
Siebelmann S, Steven P, Cursiefen C. [Intraoperative Optical Coherence Tomography In Deep Anterior Lamellar Keratoplasty]. Klin Monbl Augenheilkd. 2016 Jun;233(6):717-21.
Tahmaz V, Gehlsen U, Sauerbier L, Holtick U, Engel L, Radojska S, Petrescu-Jipa VM, Scheid C, Hallek M, Gathof B, Cursiefen C, Steven P. Treatment of severe chronic ocular graft-versus-host disease using 100% autologous serum eye drops from a sealed manufacturing system: a retrospective cohort study. Br J Ophthalmol. 2016 Jun 6. pii: bjophthalmol-2015-307666.
Engel LA, Wittig S, Bock F, Sauerbier L, Scheid C, Holtick U, Chemnitz JM,Hallek M, Cursiefen C, Steven P (2015) Meibography and meibomian gland measurements in ocular graft-versus-host disease. Bone Marrow Transplant. 50(7):961-7.
Gehlsen U, Szaszák M, Gebert A, Koop N, Hüttmann G, Steven P (2015) Non-Invasive Multi-Dimensional Two-Photon Microscopy enables opticalfingerprinting (TPOF) of immune cells. J Biophotonics. 8(6):466-79.
Siebelmann S, Gehlsen U, Hüttmann G, Koop N, Bölke T, Gebert A, Stern ME, Niederkorn JY, Steven P (2013) Development, alteration and real time dynamics of conjunctiva-associated lymphoid tissue. PLoS One. 8:e82355.
Steven P, Bock F, Hüttmann G, Cursiefen C (2011) Intravital two-photon microscopy of immune cell dynamics in corneal lymphatic vessels. PLoS One. 6:e26253.
Steven P, Rupp J, Hüttmann G, Koop N, Lensing C, Laqua H, Gebert A (2008) Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue. Invest Ophthalmol Vis Sci. 49:1512-7.