Curriculum Vitae

Prof. Dr. med. Arnd Heiligenhaus, FEBO

Department of Ophthalmology
St. Franziskus Hospital
Hohenzollernring 74
48145 Münster, GERMANY
Tel. (+49) 251-9352711
Fax (+49) 251-9350819
e-mail: arnd.heiligenhaus@uveitis-zentrum.de

Scientific career

1980-1986 Medical School, University of Bochum, Germany

1987-1988 Residency, German Military Hospital Amberg, Department of Ophthalmology

1988-1991 Residency, Department of Ophthalmology, University of Essen, Germany

1991-1993 Fellowship, Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, USA

1993-1999 Senior physician, Department of Ophthalmology, University of Essen, Diseases of the anterior eye segment

1999- Head, Department of Ophthalmology, St. Franziskus Hospital, Münster, Germany, Clinic for inflammatory eye diseases and uveitis.

2000 Managing Director of the Research Laboratory „Ophtha-Lab“ at St. Franziskus Hospital, Münster

2013 Research scientist, Institute of Experimental Ophthalmology, University of Münster

2015- Principal Investigator of Project 8 “The role of interleukin (IL)-10 in the pathogenesis of autoimmune uveitis in mice and man” in the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Uveitis Center, St. Franziskus Hospital, Münster

Scientific degrees

1987Doctorate degree (Dr. med.), University of Bochum, Germany

1993 Board examinations for specialty area Ophthalmology

1996 Habilitation, Department of Medicine, University of Essen, Germany, Specialty area: Ophthalmology

2002 Extraordinary Professor of Ophthalmology, Department of Ophthalmology, University of Essen, Germany

2007 Fellow of the European Board of Ophthalmology

Prizes and honors

2006 Research Award of the German Opthalmological Surgeons, Nuremberg

2009 Clinical Uveitis Research Award, International Ocular Inflammation Society, Prague

2010 Mauno Vannas Medal, Association of Norwegian Ophthalmology, Oulu

2013 Pfizer Research Award, Leipzig

Selected publications

Cursiefen C, Bock F, Clahsen T, Regenfuss B, Reis A, Steven P, Heindl LM, Bosch JJ, Hos D, Eming S, Grajewski R, Heiligenhaus A, Fauser S, Austin J, Langmann T. [New Therapeutic Approaches in Inflammatory Diseases of the Eye – Targeting Lymphangiogenesis and Cellular Immunity: Research Unit FOR 2240 Presents Itself]. Klin Monbl Augenheilkd. 2017 May;234(5):679-685.

Böhm MR, Tappeiner C, Breitbach MA, Zurek-Imhoff B, Heinz C, Heiligenhaus A. Ocular Hypotony in Patients With Juvenile Idiopathic Arthritis-Associated Uveitis. Am J Ophthalmol. 2017 Jan;173:45-55.

Tappeiner C, Mesquida M, Adán A, Anton J, Ramanan AV, Carreno E, Mackensen F, Kotaniemi K, de Boer JH, Bou R, de Vicuña CG, Heiligenhaus A. Evidence for Tocilizumab as a Treatment Option in Refractory Uveitis Associated with Juvenile Idiopathic Arthritis. J Rheumatol. 2016 Dec;43(12):2183-2188.

Walscheid K, Weinhage T, Foell D, Heinz C, Kasper M, Heiligenhaus A. Phenotypic changes of peripheral blood mononuclear cells upon corticosteroid treatment in idiopathic intermediate uveitis. Clin Immunol. 2016 Oct 28. pii: S1521-6616(16)30534-4. [Epub ahead of print]

Jaffe GJ, Dick AD, Brézin AP, Nguyen QD, Thorne JE, Kestelyn P, Barisani-Asenbauer T, Franco P, Heiligenhaus A, Scales D, Chu DS, Camez A, Kwatra NV, Song AP, Kron M, Tari S, Suhler EB. Adalimumab in Patients with Active Noninfectious Uveitis. N Engl J Med. 2016 Sep 8;375(10):932-43.

Tappeiner C, Schenck S, Niewerth M, Heiligenhaus A, Minden K, Klotsche J. Impact of Antiinflammatory Treatment on the Onset of Uveitis in Juvenile Idiopathic Arthritis: Longitudinal Analysis From a Nationwide Pediatric Rheumatology Database. Arthritis Care Res (Hoboken). 2016 Jan;68(1):46-54.

Walscheid K, Heiligenhaus A, Holzinger D, Roth J, Heinz C, Tappeiner C, Kasper M, Foell D. Elevated S100A8/A9 and S100A12 Serum Levels Reflect Intraocular Inflammation in Juvenile Idiopathic Arthritis-Associated Uveitis: Results From a Pilot Study. Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7653-60.

Tappeiner C, Klotsche J, Schenck S, Niewerth M, Minden K, Heiligenhaus A. Temporal change in prevalence and complications of uveitis associated with juvenile idiopathic arthritis:data from a cross-sectional analysis of a prospective nationwide study. Clin Exp Rheumatol. 2015;33(6):936-44.

Krawczyk A, Dirks M, Kasper M, Buch A, Dittmer U, Giebel B, Wildschütz L, Busch M, Goergens A, Schneweis KE, Eis-Hübinger AM, Sodeik B, Heiligenhaus A, Roggendorf M, Bauer D. Prevention of herpes simplex virus induced stromal keratitis by a glycoprotein B-specific monoclonal antibody. PLoS One. 2015 Jan 14;10(1):e0116800.

Thanos S, Böhm MR, Meyer zu Hörste M, Prokosch-Willing V, Hennig M, Bauer D, Heiligenhaus A. Role of crystallins in ocular neuroprotection and axonal regeneration. Prog Retin Eye Res. 2014 Sep;42:145-61.

Tappeiner C, Miserocchi E, Bodaghi B, Kotaniemi K, Mackensen F, Gerloni V, Quartier P, Lutz T, Heiligenhaus A. Abatacept in the treatment of severe, longstanding, and refractory uveitis associated with juvenile idiopathic arthritis. J Rheumatol. 2015;42(4):706-11.

Walscheid K, Hennig M, Heinz C, Wasmuth S, Busch M, Bauer D, Dietzel M, Deeg CA, Heiligenhaus A. Correlation between disease severity and presence of ocular autoantibodies in juvenile idiopathic arthritis-associated uveitis. Invest Ophthalmol Vis Sci. 2014 24;55(6):3447-53.

Busch M, Bauer D, Hennig M, Wasmuth S, Thanos S, Heiligenhaus A. Effects of systemic and intravitreal TNF-a inhibition in experimental autoimmune uveoretinitiis. Invest Ophthalmol Vis Sci 2013;54: 39-46.

Hennig M, Bauer D, Wasmuth S, Busch M, Walscheid K, Thanos S, Heiligenhaus A. Everolimus improves experimental autoimmune uveoretinitis. Exp Eye Res 2012;105: 43-52.

Bauer D, Wasmuth S, Hennig M, Baehler H, Steuhl KP, and Heiligenhaus A. Amniotic membrane transplantation induces apoptosis in T lymphocytes in murine corneas with experimental herpetic stromal keratitis. Invest Ophthalmol Vis Sci 2009;50:3188-3198.

Heiligenhaus A, Niewerth M, Ganser G, Heinz C, Minden K. German Uveitis in Childhood Study Group Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines. Rheumatology 2007;46: 1015-1019.

Heiligenhaus A, Li HF, Yang Y, Wasmuth S, Steuhl KP, Bauer D Transplantation of amniotic membrane in murine herpes stromal keratitis modulates matrix metalloproteinases in the cornea. Invest Ophthalmol Vis Sci 2005;46: 4079-4085