PD Dr. med. Mario Matthaei, FEBO

Scientific career

2015- Clinician-Scientist (Gerok) at the Post-Doc level in Project 2 “Identification of novel endogenous modulators of (inflammatory) lymphangiogenesis by analyzing mouse strain-specific differences” in the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne

2017 Habilitation in the Dept. of Ophthalmology, University of Cologne. Habilitation thesis title: “Molecular studies on the pathogenesis of fuchs endothelial corneal dystrophy”

2017- Principal Investigator of the independent DFG project “Molecular investigations of miR-20-associated deposits of extra-cellular matrix in the course of Fuchs endothelial dystrophy”, which is an associated project of the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne

2018- Affiliated Clinician-Scientist at the Post-Doc level in Project P2 “Identification of novel endogenous modulators of developmental and inflammatory lymphangiogenesis by analyzing mouse strain-specific differences” in the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne

Selected publications

Hribek A, Clahsen T, Horstmann J, Siebelmann S, Loreck N, Heindl LM, Bachmann BO, Cursiefen C, Matthaei M. Fibrillar Layer as a Marker for Areas of Pronounced Corneal Endothelial Cell Loss in Advanced Fuchs Endothelial Corneal Dystrophy. Am J Ophthalmol. 2021 Feb;222:292-301. Loreck N, Adler W, Siebelmann S, Rokohl AC, Heindl LM, Cursiefen C, Bachmann BO, Matthaei M. Morning Myopic Shift and Glare in Advanced Fuchs Endothelial Corneal Dystrophy. Am J Ophthalmol. 2020 May;213:69-75

Matthaei M, Hribek A, Clahsen T, Bachmann B, Cursiefen C, Jun AS. Fuchs Endothelial Corneal Dystrophy: Clinical, Genetic, Pathophysiologic, and Therapeutic Aspects. Annu Rev Vis Sci. 2019 Sep 15;5:151-175. Hos D, Matthaei M, Bock F, Maruyama K, Notara M, Clahsen T, Hou Y, Le VNH, Salabarria AC, Horstmann J, Bachmann BO, Cursiefen C. Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation. Prog Retin Eye Res. 2019 Nov;73:100768.

Matthaei M, Leitl C, Cursiefen C, Heindl LM. Correlation of extracellular matrix-related gene expression with objective Fuchs endothelial corneal dystrophy severity. Clin Exp Ophthalmol. 2019 Jul;47(5):671-673.

Matthaei M, Sandhaeger H, Hermel M, Adler W, Jun AS, Cursiefen C, Heindl LM. Changing Indications in Penetrating Keratoplasty: A Systematic Review of 34 Years of

Matthaei M, Sandhaeger H, Hermel M, Adler W, Jun AS, Cursiefen C, Heindl LM. Changing Indications in Penetrating Keratoplasty: A Systematic Review of 34 Years of Global Reporting. Transplantation. 2017 Jun;101(6):1387-1399.

Toyono T, Usui T, Villarreal G Jr, Kallay L, Matthaei M, Vianna LM, Zhu AY, Kuroda M, Amano S, Jun AS. MicroRNA-29b Overexpression Decreases Extracellular Matrix mRNA and Protein Production in Human Corneal Endothelial Cells. Cornea. 2016 Nov;35(11):1466-1470.

Matthaei M, Gillessen J, Muether PS, Hoerster R, Bachmann BO, Hueber A, Cursiefen C, Heindl LM. Author Response: Transforming Growth Factor Beta Switch in Aqueous Humor of Patients With Fuchs’ Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):773.

Matthaei M, Gillessen J, Muether PS, Hoerster R, Bachmann BO, Hueber A, Cursiefen C, Heindl LM. Epithelial-Mesenchymal Transition (EMT)-Related Cytokines in the Aqueous Humor of Phakic and Pseudophakic Fuchs’ Dystrophy Eyes. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2749-54.

Matthaei M, Zhu AY, Kallay L, Eberhart CG, Cursiefen C, Jun AS. Transcript profile of cellular senescence-related genes in Fuchs endothelial corneal dystrophy. Exp Eye Res. 2014 Dec;129:13-7.

Matthaei M, Hu J, Kallay L, Eberhart CG, Cursiefen C, Qian J, Lackner EM, Jun AS. Endothelial cell microRNA expression in human late-onset Fuchs’ dystrophy. Invest Ophthalmol Vis Sci. 2014 Jan 9;55(1):216-25.

Matthaei M, Hu J, Meng H, Lackner EM, Eberhart CG, Qian J, Hao H, Jun AS. Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs’ endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2013 Mar 15;54(3):1931-40.

Matthaei M, Lackner EM, Meng H, Hicks JL, Meeker AK, Eberhart CG, Jun AS. Tissue microarray analysis of cyclin-dependent kinase inhibitors p21 and p16 in Fuchs dystrophy. Cornea. 2013 Apr;32(4):473-8.

Matthaei M, Meng H, Meeker AK, Eberhart CG, Jun AS. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci. 2012 Sep 28;53(10):6718-27.

Matthaei M, Meng H, Bhutto I, Xu Q, Boelke E, Hanes J, Jun AS. Systematic assessment of microneedle injection into the mouse cornea. Eur J Med Res. 2012 Jun 20;17:19.

Meng H, Matthaei M, Ramanan N, Grebe R, Chakravarti S, Speck CL, Kimos M, Vij N, Eberhart CG, Jun AS. L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy. Invest Ophthalmol Vis Sci. 2013 Mar 28;54(3):1887-97.

Jun AS, Meng H, Ramanan N, Matthaei M, Chakravarti S, Bonshek R, Black GC, Grebe R, Kimos M. An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis. Hum Mol Genet. 2012 Jan 15;21(2):384-93.