Three thematic areas

lymphatic vessels

Lymphatic vessels are an important part of the “afferent” arm of inflammatory and immune responses. Via lymphatic vessels, antigen-presenting cells and antigens from the periphery enter the regional lymph nodes to induce local immune responses.

microglia

Microglia-mediated retinal immune processes are an early occurring pathophysiological hallmark of hereditary retinal dystrophies, age-related macular degeneration, diabetic retinopathy and glaucoma.

macrophages

Macrophages along with resident microglial cells of the retina appear to play a key role in all ocular inflammatory processes to be studied here. Thus, certain polarized phenotypes of macrophages mesh intimately with pathological lymphangiogenesis.

Background and specific aims

Background

The eye is the most important human sensory organ with which we perceive 90 percent of all information in our environment. The optical transparency as well as a structural and functional integrity of the eye is essential for good vision.

Specific aims

The general goal of the FOR 2240 is the concerted investigation of the so far still poorly understood pathogenesis of aberrant immune processes of the eye and the development of innovative new diagnostic and therapeutic concepts.

News

Prof. De Paiva in Cologne

We were honored to welcome Prof. De Paiva last Tuesday (12th of November 2019) at the Hospital University of Cologne. The Ocular Surface Group, led by Prof. Philipp Steven and Dr. Uta Gehlsen invited Prof. De Paiva to collaborate on aging aspects in dry-eye disease and ocular Graft-versus-Host Disease. The latter is main focus ofContinue reading

Physician attends international Young Physician Leaders Programm

Priv. – Doz. Dr. Sebastian Siebelmann, consulting physician at the department of ophthalmology of the University Hospital Cologne attended the Young Physician Leaders Program (YPL) of the Interacademy Partnership Alliance (IAP) and the M8 Alliance of Academic Health Centers and Medical Universities. The YPL-Program brings young ambitious leaders from all over the world, which wereContinue reading

NEW European Union COST ACTION on Aniridia co-chaired in Cologne

ANIRIDIA-NET(https://aniridia-net.eu/) is a pan-European bottom-up network of researchers, ophthalmologist, trainees, aniridia patient organizations, industry and special interest groups funded by the European Cooperation in Science and Technology (COST) program (link) to improve aniridia clinical management and promote innovative research and development of new alternatives for its diagnosis and treatment. The COST Action runs from 2019-2023Continue reading

Events

The research unit FOR 2240 hosts a number of different formal events, including regular internal meetings of all principle investigators, invited guest lectures, visiting professors, retreats, and a symposium to be held near the end of the initial funding period.

Links

The research unit FOR 2240 is embedded in various institutional contexts and has close cooperative ties to various other projects and networks.