Three thematic areas

lymphatic vessels

Lymphatic vessels are an important part of the “afferent” arm of inflammatory and immune responses. Via lymphatic vessels, antigen-presenting cells and antigens from the periphery enter the regional lymph nodes to induce local immune responses.

microglia

Microglia-mediated retinal immune processes are an early occurring pathophysiological hallmark of hereditary retinal dystrophies, age-related macular degeneration, diabetic retinopathy and glaucoma.

macrophages

Macrophages along with resident microglial cells of the retina appear to play a key role in all ocular inflammatory processes to be studied here. Thus, certain polarized phenotypes of macrophages mesh intimately with pathological lymphangiogenesis.

Background and specific aims

Background

The eye is the most important human sensory organ with which we perceive 90 percent of all information in our environment. The optical transparency as well as a structural and functional integrity of the eye is essential for good vision.

Specific aims

The general goal of the FOR 2240 is the concerted investigation of the so far still poorly understood pathogenesis of aberrant immune processes of the eye and the development of innovative new diagnostic and therapeutic concepts.

News

Alexander von Humboldt Fellow – Professor Dr. Takahiko Hayashi

Professor Dr. Takahiko Hayashi from the department of ophthalmology at Yokohama Minami Kyosai Hospital in Yokohama, Japan, is currently a guest and Alexander von Humboldt Fellow of experienced scientists at the Department of ophthalmology, University Hospital of Cologne, under the supervision of Prof. Dr. Claus Cursiefen. Professor Hayashi is an internationally established cornea specialist andContinue reading

Prof. Hamrah – scientist of Cell Molecular & Developmental Biology, Immunology and Neuroscience

Prof. Pedram Hamrah from the Tufts University School of Medicine in Boston, USA visited the University Clinic of Cologne in May 2019. He had meetings with the FOR2240 scientists Dr. Notara, Dr. Clahsen, Dr. Hos and Dr. Bock and they discussed topics including “the role of limbal stem cells in corneal neovascularisation”and “Tyrosinase is aContinue reading

Pole position in Germany for the Department of Ophthalmology at University of Cologne

Number 1 in scientific publications and impact factor The demand for research within ophthalmology is and will be high. Today many conditions of the eye can be treated successfully – also thanks to intensive and continuing research. But there are still many research questions pending. And the pressure to actContinue reading

Events

The research unit FOR 2240 hosts a number of different formal events, including regular internal meetings of all principle investigators, invited guest lectures, visiting professors, retreats, and a symposium to be held near the end of the initial funding period.

Links

The research unit FOR 2240 is embedded in various institutional contexts and has close cooperative ties to various other projects and networks.