Angiogenesis, lymphangiogenesis and cellular immunity in inflammatory diseases of the eye making vision better longer gaining the knowledge

Three thematic areas

lymphatic vessels

Lymphatic vessels are an important part of the “afferent” arm of inflammatory and immune responses. Via lymphatic vessels, antigen-presenting cells and antigens from the periphery enter the regional lymph nodes to induce local immune responses.

microglia

Microglia-mediated retinal immune processes are an early occurring pathophysiological hallmark of hereditary retinal dystrophies, age-related macular degeneration, diabetic retinopathy and glaucoma.

macrophages

Macrophages along with resident microglial cells of the retina appear to play a key role in all ocular inflammatory processes to be studied here. Thus, certain polarized phenotypes of macrophages mesh intimately with pathological lymphangiogenesis.

Background and specific aims

Background

The eye is the most important human sensory organ with which we perceive 90 percent of all information in our environment. The optical transparency as well as a structural and functional integrity of the eye is essential for good vision.

Specific aims

The general goal of the FOR 2240 is the concerted investigation of the so far still poorly understood pathogenesis of aberrant immune processes of the eye and the development of innovative new diagnostic and therapeutic concepts.

News

German Ophthalmological Society (DOG) – Professor Dr. Claus Cursiefen elected as Secretary General

The German Ophthalmological Society (DOG) elected Professor Dr. Claus Cursiefen as Secretary General for the period of four years during their 118th annual meeting in Berlin. The renowned eye specialist´s tasks as Secretary General are assuring continuity of fundamental issues and liaising with other public and private institutions. Furthermore, Professor Cursiefen will govern the DOGContinue reading

2nd Shanghai-Cologne Ophthalmic Research Meeting

After the signature of a cooperation agreement in 2019 between the Departments of Ophthalmology of the Tongji University Shanghai and University Hospital Cologne, the 2nd Shanghai-Cologne Ophthalmic Research Meeting took place online on 5th December during the 2020 China-Germany New technology forum of Tongji Ophthalmology. Professor Dr. Claus Cursiefen, Chairman of the Department of OphthalmologyContinue reading

Antonia Howaldt accepted into the Cologne Clinician Scientist Program

We proudly announce that Antonia Howaldt has been accepted into the Clinician Scientist Program of the Medical Faculty of the University of Cologne. Designed for physician-scientists seeking careers that combine research with clinical training, the Cologne Clinician Scientist Program offers a three-year program with protected research time supporting translational research (50% clinical training, 50% research),Continue reading

Events

The research unit FOR 2240 hosts a number of different formal events, including regular internal meetings of all principle investigators, invited guest lectures, visiting professors, retreats, and a symposium to be held near the end of the initial funding period.

Links

The research unit FOR 2240 is embedded in various institutional contexts and has close cooperative ties to various other projects and networks.