Three thematic areas

lymphatic vessels

Lymphatic vessels are an important part of the “afferent” arm of inflammatory and immune responses. Via lymphatic vessels, antigen-presenting cells and antigens from the periphery enter the regional lymph nodes to induce local immune responses.

microglia

Microglia-mediated retinal immune processes are an early occurring pathophysiological hallmark of hereditary retinal dystrophies, age-related macular degeneration, diabetic retinopathy and glaucoma.

macrophages

Macrophages along with resident microglial cells of the retina appear to play a key role in all ocular inflammatory processes to be studied here. Thus, certain polarized phenotypes of macrophages mesh intimately with pathological lymphangiogenesis.

Background and specific aims

Background

The eye is the most important human sensory organ with which we perceive 90 percent of all information in our environment. The optical transparency as well as a structural and functional integrity of the eye is essential for good vision.

Specific aims

The general goal of the FOR 2240 is the concerted investigation of the so far still poorly understood pathogenesis of aberrant immune processes of the eye and the development of innovative new diagnostic and therapeutic concepts.

News

New study identifies a novel role for TSPO in immune-related eye disease providing new treatment options for age-related macular degeneration (AMD)

In a cooperative approach the team around Thomas Langmann (Laboratory of the Exp. Immunology of the Eye at the Center for Ophthalmology and the CMMC) together with the team of Michael Schramm (Inst. of Med. Microbiology, Immunology and Hygiene) at the Univ. Hospital of Cologne and the Univ. of Cologne has identified a new mechanismContinue reading

Retreat 2020 in times of Corona

A few days before the FOR2240 wanted to have the retreat in a cozy cottage in Bedburg (https://danielshof.de/), the Corona wave started to hit Cologne. Consequently, every larger meeting had to be canceled and the FOR2240 held a small full-day meeting – only the principal investigators – in the Lecture Room of the Department ofContinue reading

FOR 2240 Retreat 2019 Abbey Brauweiler

Thirdy-two members of the German Research Foundation (DFG) Research Unit FOR 2240 met on the 8th of March 2019 in the Abbey of Brauweiler. It was the first time the principal investigators of the FOR 2240 and associated scientists and clinicians met in this quiet and peaceful environment to present and discuss recent progress inContinue reading

Events

The research unit FOR 2240 hosts a number of different formal events, including regular internal meetings of all principle investigators, invited guest lectures, visiting professors, retreats, and a symposium to be held near the end of the initial funding period.

Links

The research unit FOR 2240 is embedded in various institutional contexts and has close cooperative ties to various other projects and networks.