Three thematic areas

lymphatic vessels

Lymphatic vessels are an important part of the “afferent” arm of inflammatory and immune responses. Via lymphatic vessels, antigen-presenting cells and antigens from the periphery enter the regional lymph nodes to induce local immune responses.

microglia

Microglia-mediated retinal immune processes are an early occurring pathophysiological hallmark of hereditary retinal dystrophies, age-related macular degeneration, diabetic retinopathy and glaucoma.

macrophages

Macrophages along with resident microglial cells of the retina appear to play a key role in all ocular inflammatory processes to be studied here. Thus, certain polarized phenotypes of macrophages mesh intimately with pathological lymphangiogenesis.

Background and specific aims

Background

The eye is the most important human sensory organ with which we perceive 90 percent of all information in our environment. The optical transparency as well as a structural and functional integrity of the eye is essential for good vision.

Specific aims

The general goal of the FOR 2240 is the concerted investigation of the so far still poorly understood pathogenesis of aberrant immune processes of the eye and the development of innovative new diagnostic and therapeutic concepts.

News

PhD studentship 65% open in Project 5

Project 5 “Myeloid cell function in corneal hem- and lymphangiogenesis” ) in the Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” (Speaker: Univ.-Prof. Dr. med. Claus Cursiefen, FEBO, FARVO and Vice-Speaker: Univ.-Prof. Dr. rer. nat. Thomas Langmann) in the Department of Ophthalmology atContinue reading

Four Million Euros for Better Vision for Longer

DFG Research Unit FOR 2240 begins its second round Good vision is only possible when the anterior part of the eye is transparent. However, when inflammatory reactions in the eye occur, these lead to loss of transparency and sometimes even blindness. An example of such a reaction is the pathological formation of blood vessels andContinue reading

Prof. Langmann wins the Dr. Gaide AMD prize

On 23 June 2018, Univ.-Prof. Dr. rer. nat. Thomas Langmann was awarded the Dr. Gaide AMD prize at the annual meeting of the Retina Society in Bonn. Prof. Langmann is the Chair of Experimental Immunology of the Eye in the Department of Ophthalmology, Medical Faculty, University of Cologne and Vice-Speaker of the DFG Research UnitContinue reading

Events

The research unit FOR 2240 hosts a number of different formal events, including regular internal meetings of all principle investigators, invited guest lectures, visiting professors, retreats, and a symposium to be held near the end of the initial funding period.

Links

The research unit FOR 2240 is embedded in various institutional contexts and has close cooperative ties to various other projects and networks.